IL17A and arthropathy: Collectively, these data suggest that IL‐22 has dual pro‐ and antiinflammatory roles in CIA, with early, systemic IL‐17 and IL‐22 (Th22) responses cooperating to drive pathogenesis, while later, IL‐22 acts at the site of inflammation to counterregulate IL‐17 proinflammatory signaling and promote resolution of joint disease.