The observed upregulation of RELB might reflect the activation of an alternative NF-κB pathway to limit inflammation 45,46, whereas upregulation of the TLR family of pattern-recognition receptors, TLR2, may indicate chronic inflammation or tumor immune escape mechanisms following exposure to damage-associated molecular patterns (DAMPs) released from the injured tissue/tumor 47. The gene discussed is NFKB1; the disease is neoplasm.