Moreover, by comparing the IC50 values of the WT, R1, and R2 glioblastoma cell lines to the corresponding EFEMP1 expression levels, we identified a positive correlation between these two variables (r2=0.56, p=0.021) (Supplementary Fig. S1), suggesting that EFEMP1 expression is associated with a TMZ-resistant phenotype. Here, EFEMP1 is linked to glioblastoma.