However, overexpression of ΔSAP-Mkl1 led to a significant reduction in the proliferative and migratory ability of HC11 epithelial cells, either through a dominant-negative effect of ΔSAP-Mkl1 on SRF-mediated action and/or a positive impact of the SAP-dependent Mkl1 target genes on these functions important for cancer progression. This evidence concerns the gene MRTFA and cancer.