The case group (using beta-blockers, n = 74) and the control group (using non-beta-blockers, n = 114) were not significantly different with regard to age, gender, body mass index, comorbidities, reason for ICU admission, APACHE II score, ABG on ICU admission, CRP values, or the presence of sepsis and septic shock (Table 1). This evidence concerns the gene CRP and Sepsis.