LMNB1 and adult-onset autosomal dominant demyelinating leukodystrophy: The LMNB1BAC mouse model overexpressing lamin B1, mimicking human ADLD, will be a critical resource for further investigations in vivo, because while increased lamin B1 expression in neurons or glia causes lethality in Drosophila[18], the striking similarities between human and murine oligodendrocytes may hasten investigations toward clinical development.