In this respect, other studies show that MG132 proteasome inhibition induces apoptosis in glioblastoma cells through inhibition of the PI3K/Akt and NF-кB pathways [67], and that this inhibitor disrupts DOX-induced NF-кB activation in DOX-resistant K562 erythromyeloblastoid leukemia cells [68]. The gene discussed is AKT1; the disease is leukemia.