In leukemic and other tumor cells, it has been observed that DOX can intercalate with DNA, inducing histone eviction from open chromosomal areas and taking part in oxidation-reduction reactions [38-40] and a mechanism has been disclosed by which DOX induces apoptosis in tumor cells, consisting of the activation of the factor CREB3L1, which activates transcription of genes that disrupt the cell cycle [41]. Here, CREB3L1 is linked to neoplasm.