T2D subjects with BMI ≥ 30 kg/m2 had higher CRP levels (5.2 ± 4.8 mg/l vs 3.7 ± 4.3 mg/l; p = 0.029), while those previously treated with metformin had lower levels of IL-6 (1.51 ± 3.86 ng/l vs 2.23 ± 4.4 ng/l; p = 0.046). This evidence concerns the gene IL6 and type 2 diabetes mellitus.