In the present study, we investigated OLFM4 alteration during endometrial carcinogenesis, analysed the correlation of OLFM4 expression with oestrogen receptor signalling and regulation of OLFM4 expression in endometrial adenocarcinoma, and examined the effects of OLFM4 on biological features of endometrial carcinoma cells and progression of endometrial adenocarcinoma. Here, OLFM4 is linked to endometrial carcinoma.