The theory frameworks three predictions in regards to the role of MnSOD and cancer: (1) all cancers should possess decreased amounts of MnSOD activity compared to their normal tissue counterparts, (2) replacement of MnSOD in tumor cells should abrogate the malignant phenotype, and (3) normal cells that lose MnSOD will in turn become malignant. The gene discussed is SOD2; the disease is neoplasm.