HTR1A and epilepsy: Experimental data from animal models and humans reveal that serotonergic neurotransmission is significantly involved in pathogenesis of epilepsy: depletion of brain serotonin in genetically epilepsy-prone rat model of audiogenic seizures (45, 46); lower seizure thresholds in mutants mice lacking 5-HT1A or 5-HT2C receptor subtype (47, 48); decrease in 5-HT1A receptor binding in epileptogenic zone of TLE patients (49).