Disease duration of C9ORF72-related ALS was significantly shorter than in patients with mutations in SOD1, TARDBP or other familial ALS cases, but did not differ from FUS cases, whilst there was an older age of onset in C9ORF72-related ALS compared to SOD1 and FUS-related ALS, but not when compared with TARDBP and other familial ALS cases. Here, TARDBP is linked to amyotrophic lateral sclerosis.