The second most frequent PIP was aspirin with no history of coronary, cerebral, or peripheral vascular symptoms or occlusive event (n = 112, 3.2 %), followed by benzodiazepines in those prone to falls (n = 40, 1.2 %) and aspirin with a past history of peptic ulcer disease without a histamine H2 receptor antagonist or proton pump inhibitor (n = 38, 1.1 %). Here, HRH2 is linked to peptic ulcer disease.