AKT1 and Alzheimer disease: We found over representation of a variety of signaling pathways—Pi3K/Akt, MAPK, neurotrophin, and Wnt signaling—synaptic pathways—glutamergic, dopaminergic, cholinergic, GABA-ergic synapses—and pathways of axon guidance, cell adhesion, long-term potentiation, and AD.