GATA3 and infection: Similarly, fewer SJL Tregs upregulated GATA3 in response to infection (Figure 4c), which may be important as GATA3 has been found to be required for functional Treg suppression in the gut.49 These data argue that although there is no correlation between susceptibility and the overall numbers of Foxp3+ Tregs, a qualitative distinction may exist in the suppressive capacity of these cells in the most resistant SJL genotype.