NFE2L2 and clear cell renal carcinoma: Analysis of available survival datasets obtained from GEO and TCGA databases showed that lower expression of Nrf2 (NFE2L2) is associated with a significantly poorer outcome in skin cutaneous melanoma (SKCM) (P = 0.0341) and in kidney clear cell carcinoma (KIRC) (P = 0.0203) (Figure 7B).