HOXB7 and neoplasm: In CC lines, miR-196b is downregulated (Table 1) [18] and it has been observed that downexpression of miR-196b in human CC likely promotes tumor cell proliferation via increased activity of the HOXB7 transcription factor, which in turn can upregulate several prosurvival pathways, ultimately leading to tumor progression (Figure 1) [35, 36].