Interestingly, the CXCL12/SDF-1 chemokine, which is constitutively secreted by human lung epithelium cells, has been shown to enhance the invasiveness of chondrosarcoma cells by increasing αvβ3 integrin expression, through the CXCR4/ERK/NF-κB pathway. The gene discussed is CXCR4; the disease is chondrosarcoma.