Macrophage migration-inhibitory factor (MIF), a pro-inflammatory cytokine involved in macrophage migration and activation, is able to enhance the migration of chondrosarcoma cells by increasing αvβ3 integrin expression, mediated via PI3K/Akt/NF-κB signaling [52] (Table 1). This evidence concerns the gene NFKB1 and chondrosarcoma.