In pancreatic cancer cells, the α6β1 and α3β1 integrins interact with laminin-1 to mediate cell migration; this process involves the upregulation of CXC chemokine receptor 4 (CXCR4) and IL-8 expression in response to the chemokine ligand CXCL12, also known as stromal cell-derived factor-1 (SDF-1) [42]. This evidence concerns the gene CXCL12 and familial pancreatic carcinoma.