TRB3 is upregulated in the skeletal muscle of patients with Type II diabetes and TRB3 over-expression in muscle cells blocks insulin-stimulated glucose transport and impairs phosphorylation of AKT, extracellular-signal regulated kinase (ERK), and insulin receptor substrate-1 (IRS1) [54]. The gene discussed is TRIB3; the disease is type 2 diabetes mellitus.