In postmitotic neuronally differentiated PC12 cells, coexpression of TRB3 with ATF4 prevents ATF4-induced apoptosis [110] and TRB3 can function as a pro-survival factor in glucose-starved PC-3 prostate cancer cells [111] and bone marrow-derived mast cells [103]. This evidence concerns the gene TRIB3 and prostate carcinoma.