Interestingly, two haplotypes in the chromosomal region (five SNPs in a 100 kb region of chromosome 14) encompassing KIAA0391 and PSMA6 genes, 1A-2G-3C-4A-5A and 1A-2G-3G-4A-5A, show increased risk of both CAD and myocardial infarction (MI), while another haplotype, 1T-2G-3C-4G-5A, showed decreased risk of CAD and MI [85]. The gene discussed is PRORP; the disease is myocardial infarction.