Using genome-wide homozygosity mapping, a homozygous missense mutation (c.224C > T, Thr75Met) in the proteasome gene PSMB8 that encodes the β5i (LMP7) subunit was detected in two pedigrees from Portugal and Mexico with JMP syndrome [54]. This evidence concerns the gene PSMB8 and proteosome-associated autoinflammatory syndrome.