Four epitopes of mycobacterial HSP65 (amino acid sequences 111-25, 154-72, 219-33, and 311-26) and their human counterparts with 50–80% homology were recognized to be immunodominant antigens for T-and B-cell responses in BD in studies from UK, Japan, and Turkey [20–23]. This evidence concerns the gene HSPD1 and Behcet disease.