TNF and Behcet disease: In this context, stimulation of peripheral blood mononuclear cells (PBMC) with human HSP60 peptide 336-51 produced IFN-γ, tumor-necrosis factor-α (TNF-α), and IL-12, whereas Th2 cytokines IL-4 and IL-10 suppressed the proliferative responses in BD [17, 25].