Alugupalli et al. reported that “Lactoferrin interacts with A. actinomycetemcomitans, which is a causative microorganism in aggressive periodontitis and its colonization may occur more readily in an environment containing lactoferrin with low iron levels and depressed level of iron found in lactoferrin may be resulted from both the iron-sequestering pathogenic bacteria and reduced capacity of lactoferrin to bind iron in the saliva of aggressive periodontitis patients [37, 79].” The gene discussed is LTF; the disease is periodontitis.