Compared to the subjects with DN, CKD disease control subjects had higher total cholesterol, LDL, HDL, CCR, and eGFR levels, and they had lower systolic pressure, diastolic pressure, fasting glucose, 2-h glucose, fasting insulin, BUN, and creatinine levels (Table 1, all p<0.05). This evidence concerns the gene INS and liver dysplastic nodule.