As shown in Figure 2B, 2C, and 2D, serum CXCL16 levels paralleled trends of creatinine, BUN, and uric acid levels among T2DM, DN, and healthy subjects, suggesting that circulating CXCL16 levels may be related to the change of renal function in these patients. The gene discussed is CXCL16; the disease is type 2 diabetes mellitus.