CISH and cancer: The aim of the present study was to further investigate the molecular mechanism modulated by statins on cancer cells, by examining the effects of simvastatin on the JAK/STAT/SOCS signaling pathway activated by GH in UMR-106 cells, specifically whether simvastatin was able to decrease GH signaling, modulating the JAK/STAT pathway in its activation, transcriptional activity and regulation by SOCS proteins.