FDA-approved drugs for the treatment of wet AMD include Lucentis (Ranibizumab), Eylea (Aflibercept), and Macugen (Pegaptanib), all of which target VEGF to slow the growth of abnormal blood vessels and reverse the increased vascular permeability associated with new vessel formation [3]–[5]. The gene discussed is VEGFA; the disease is wet macular degeneration.