As the results showing deregulation of ADNP expression in a tauopathy model paralleling endogenous tau 3R expression, and given our original data showing tau hyperphosphorylation and tangle-like formation in ADNP haploinsufficient mice (ADNP+/−) [12], we investigated if tau expression is deregulated in the cerebral cortex of ADNP+/− mice. This evidence concerns the gene MAPT and tauopathy.