IL6 and cholestasis: The presented studies suggested that the higher expression of PPARγ and NF-κB and PPARγ up-regulated/dysregulation NF-κB expression and then induced abnormal serum levels of cytokines IL-4, IL-6, IL-12 and TNF-α, which might disturb inflammatory processes and the balance of immune reaction, placental bile acid and lipids transportation, resulted in fatal cholestasis and probably one of the mechanism of ICP.