The crosstalk between PPARγ and NF-κB at the placenta and HTR-8/SVneo cells level indicates an interaction between bile acid and lipids metabolism, hepatic function injury, fetal cholestasis and fetal complications and imbalance of immune reaction and additionally inflammatory responses induced diseases, such as ICP, and lead to new insights in pathogenesis and potentially also to novel treatment strategies for ICP. The gene discussed is NFKB1; the disease is cholestasis.