The presented studies suggested that the higher expression of PPARγ and NF-κB and PPARγ up-regulated/dysregulation NF-κB expression and then induced abnormal serum levels of cytokines IL-4, IL-6, IL-12 and TNF-α, which might disturb inflammatory processes and the balance of immune reaction, placental bile acid and lipids transportation, resulted in fatal cholestasis and probably one of the mechanism of ICP. Here, TNF is linked to cholestasis.