PDGFRA and central nervous system cancer: Previous reports have indicated the role of PDGFRA signaling in the activation of Ras-Raf-MEK-ERK pathway [14], [16], [35], [36], [51], [52], and aberrant activation of Ras-Raf-MEK-ERK pathway can be causal for gliomas [26], [49], [53]–[55].