Previous reports have indicated the role of PDGFRA signaling in the activation of Ras-Raf-MEK-ERK pathway [14], [16], [35], [36], [51], [52], and aberrant activation of Ras-Raf-MEK-ERK pathway can be causal for gliomas [26], [49], [53]–[55]. Here, MAP2K7 is linked to central nervous system cancer.