PDE3A and coronary artery disorder: Using these data, other groups have documented an increased risk for coronary heart disease with an elevated proneness to anger [13], [14], [17], [51], [52], and we have found nominally significant (p<0.05) enrichment of genes associated with the negative regulation of blood pressure (GO:0045776; ABAT and VEGFC) and platelet activation (GO:0030168; FYN, VEGFC, and PDE3A) in our study of Angry Temperament (Table 3).