As the different trends of ER+/PR+/HER2+ breast cancers among heavily obese patients were apparent in Figure 1, BMI was classified into three categories based on the Chinese anthropometric parameters: BMI<24, 28>BMI≥24, and BMI≥28, which represents normal, overweight, and obesity, respectively. Here, ESR1 is linked to obesity due to melanocortin 4 receptor deficiency.