Chang and Chiu et al. found rs3811951 was associated with fasting insulin, triglycerides, and high-density lipoprotein cholesterol (P = 0.05, 0.003, 0.001, 0.04, and 0.04, respectively) [14], which may indicate the possible association of PCSK1 with risk of CAD. Here, INS is linked to coronary artery disorder.