APC and malignant colon neoplasm: In the case of colon cancer, the second top-ranked gene for loss of connectivity with  (see Table S3) is the aryl hydrocarbon receptor (AhR) that in the study of [38] turned out to have a crucial role in suppression of intestinal carcinogenesis by proteasomal degradation of -catenin, which interacts with the canonical APC-dependent pathway.