HADHB and steatosis: In particular, alterations in the expression of PPARα target genes involved in lipid catabolism (e.g. carnitine palmityltransferase 1 (Cpt1), 3-ketoacyl-CoA thiolase (Hadhb), acetyl-Coenzyme A acyltransferase 2 (Acaa2)), have been linked to the development of drug-induced steatosis [6].