Also, as the RASSF family of tumor suppressor proteins all possess an RA domain, it is possible that the G37 mutant, by having a higher affinity for the RA domain than the S35, E38 and C40 mutants, activated a RASSF-dependent tumor suppressive response that counteracted oncogenic Ral signalling [23], [60]. This evidence concerns the gene RALA and neoplasm.