The anticoagulant and endothelial-like nature of highly aggressive melanoma tumors is controlled by TF and TFPI1, but not TFPI2; TFPI1 associates with the tumor cell surface and inhibits TF, while TFPI2 is secreted by the tumor cell into the extracellular matrix and assists in plasticity of the vascular phenotype [24]. This evidence concerns the gene TFPI2 and melanoma.