BCR and B-cell chronic lymphocytic leukemia: In a separate study, phosphoprofiling of 23 CLL samples demonstrated that, while anti-IgM crosslinking alone produced minimal phosphoresponses, addition of H2O2 as a mean of signal amplification via tyrosine phosphatase inhibition could segregate patients' CLL cells in high and low responders, implying variability in the differential proximal BCR modulation within the clonal population.