BCR and B-cell chronic lymphocytic leukemia: Fig. S4), thus further supporting the multidimensional view of the BCR signaling pathway as an independent indicator of disease state. Indeed, visualization of the phosphoresponses in higher dimensions is a powerful tool to resolve disease status between a CLL and healthy B cell. Three-dimensional visualization of three phosphoresponses (pPLCγ2+, pSYK+ and either pBLNK+ or ppERK+) for all CLL and healthy samples demonstrated a clear separation of the healthy individuals' samples from the CLL patients' samples solely by virtue of the combined %pX+ values (Fig. 2D).