In a separate study, phosphoprofiling of 23 CLL samples demonstrated that, while anti-IgM crosslinking alone produced minimal phosphoresponses, addition of H2O2 as a mean of signal amplification via tyrosine phosphatase inhibition could segregate patients' CLL cells in high and low responders, implying variability in the differential proximal BCR modulation within the clonal population. This evidence concerns the gene CD40LG and B-cell chronic lymphocytic leukemia.