Using an animal model, which in DA rats induces the clinical symptoms of disease that resemble to relapsing-remitting form of MS in humans, we show herein that hepatic IL-6, TGF-β, MTs, and ER-resident HSP-gp96 have a high regulatory effect on inflammation and disturbed immune mechanisms that occur during an autoimmune response. Here, IL6 is linked to myeloid sarcoma.