In aggregate, our present data suggested that the therapeutic effect of DTX with RS on the cutaneous angiosarcoma might correlate with the induction of immunoreactive CXCR3+ Th1 cells, effector CD8+ cells, NK cells, and NKT cells by the increased levels of CXCL10 and CXCL11 production from these modified macrophages. Here, CXCR3 is linked to angiosarcoma.