Similarly, Coimbra et al., 2010 [15] reported that TNF-α, IL-23, IL-22, and IL-17 decreased significantly after both NB-UVB and PUVA treatment with a significant reduction in PASI score and suggested that the reduction in the IL-23/Th17 axis might be important in the pathogenic mechanisms of psoriasis. This evidence concerns the gene IL22 and psoriasis.