The large Ccc3 locus potentially overlaps previously described colitogenic intervals identified on chromosome 1 including the IL-10 deficiency model (Cdcs2, peak marker 33.31 cM), G-protein-deficiency-induced colitis (Gpdc2, peak marker 50.78 cM) and the Trichuris muris-induced colitis model (Tm1, peak marker between 68.58 and 76.73 cM) (Farmer et al. 2001; Borm et al. 2005; Levison et al. 2013). This evidence concerns the gene IL10 and hyperinsulinemic hypoglycemia, familial, 4.