GNAI2 and colitis: Loci on chromosome 3 have also been shown as strain-dependent contributors to lesions in a Trichuris muris-induced model of colitis (Levison et al. 2013), a G-protein alpha inhibitory 2 chain (Gnai2 −/−) mutant (Borm et al. 2005), T-bet(−/−).Rag2(−/−) double-deficient mice (Ermann et al. 2011), Gpx1(−/−).Gpx2(−/−) double-deficient mice (Esworthy et al. 2011a, b) and a H. hepaticus-induced colitis and colonic tumor model (Boulard et al. 2012).