AKT1 and neoplasm: The increased number of single tumour epithelial cells observed at the invasive front in SC+ORT primary tumours and its association with higher level of p-AKT might be explained by the previous report that AKT activation increases resistance to apoptosis induced by loss of cell attachment, a function that is required for solitary cell migration and invasion (Grille et al., 2003; Xue and Hemmings, 2013).