Levels of Smurf2 protein in ER+/PR + cancer cells (MCF-7 and T47D) and those in HER2+/ER+/PR + BT474 cells and HER2+/ER-/PR- SK-BR-3 cells were comparable with Smurf2 levels in MCF-10A cells. Here, SMURF2 is linked to cancer.