Activated, but not resting, B cells are the major producers of lymphocyte-derived brain-derived neurotrophic factor in mouse and humans [54,55] and, as brain-derived neurotrophic factor secretion by B cells supports neuronal survival both in vitro[54] and in vivo[56,57], it is imperative to discover in future studies if RHP alters post-stroke B cells to enhance the upregulation of this, and other growth factors, in the post-stroke brain. The gene discussed is BDNF; the disease is stroke disorder.