The pairs plot shows that methylation of some genes is highly correlated, e.g. IRF4, BCAT1, FOXI2, while that of SEPT9 is most closely correlated with GRASP, SDC2 and SOX21. This could reflect underlying co-ordinate methylation or high level methylation of these genes within cancer cells combined with different proportions of cancer cells within the tissue samples. The gene discussed is FOXI2; the disease is cancer.