Among the genes characterised in detail, six genes, SOX21, SLC6A15, NPY, GRASP, ST8SIA1 and ZSCAN18, as well as SEPT9, were methylated in >50% of CRC samples and were not methylated to a level of >10% in any of the matched non-neoplastic samples analysed. The gene discussed is SOX21; the disease is colorectal carcinoma.