It is notable that among the 20 genes scored as being activated, 17 have been shown in recent data sets to be commonly methylated in CRC, e.g. EFEMP1, SDC2, EDIL3 (Table 1), while two (ANK2 and MAMDC2) had not been reported to methylated in CRC. This evidence concerns the gene SDC2 and colorectal carcinoma.