SOX21 and colorectal carcinoma: 11 genes (BCAT1, COL4A2, DLX5, FGF5, FOXF1, FOXI2, GRASP, IKZF1, IRF4, SDC2 and SOX21) show very low methylation levels in wbc DNA from healthy subjects and hence are suitable for further evaluation as blood-based CRC diagnostic biomarkers.