Christopher-Stine et al. found a 7% prevalence of anti-HMGCR aAbs (as initially determined by a 100 to 200 kDa reactivity after immunoprecipitation) within a series of 225 patients with proximal muscle weakness, elevated CK, myopathic findings on electromyography, muscle edema on magnetic resonance imaging and/or features of myopathy on muscle biopsy [14]. Here, HMGCR is linked to myopathy.