Further, ALBIA-HMGCR remained negative when tested against sera from patients with different inflammatory/autoimmune conditions including RA, systemic sclerosis, SLE, DM, anti-tRNA synthetase-positive myositis or IBM, or in patients with polyclonal hypergammaglobulinemia (Figure 3A). Here, HMGCR is linked to systemic lupus erythematosus.