We found PROM1 mutation in 3 pairs of lung cancers and normal tissues, including 1 SCC and 2 ADCs with mutation frequency being 1.5% and CRTC2 mutation in 5 pairs of lung cancers and normal tissues, including 3 ADCs and 2 SCCs with mutation frequency being 2.5%. The gene discussed is PROM1; the disease is lung carcinoma.