As has been shown for the intravenous injection, the intradermal injection of LaE in BALB/c mice potentiated the infection by L. braziliensis. However, when administered by the intradermal route, a dose of LaE two orders of magnitude lower (1.25 μg) than the dose that was able to promote the infection by the intravenous route (200 μg;[8]) was enough to produce the effect. This evidence concerns the gene ACSM1 and infection.