ACSM1 and infection: The infection-enhancing activity of the largest doses of LbE was indeed significantly lower than the activivities of the same doses of LaE. This finding is consistent with that reported by Silva and collaborators[8], who found that LbE, when repeatedly administered by the intravenous route in a relatively high dose, did not exacerbate the infection of BALB/c mice by L. braziliensis.