As shown in Table 4, three variants were only detected in Marfan syndrome patients, including one nonframeshift deletion in DSC2, one missense SNPs in LRP1, and one stopgain SNP in FBN1. According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, DSC2 is involved in the Arrhythmogenic right ventricular cardiomyopathy pathway (hsa05412). The gene discussed is DSC2; the disease is Marfan syndrome.