Angiogenesis appeared to be attenuated in MDEL group relative to MDS with 17 unique genes significantly under-expressed including various collagen genes (COL1A1, COL1A2, COL3A1, COL5A1, COL18A1), proteoglycans (CSPG4), blood vessel survival factors (ANGPTL4), growth factors (FGF9) and early response genes downstream of growth factors such as ZFP36L1. Here, COL5A1 is linked to myelodysplastic syndrome.