Angiogenesis appeared to be attenuated in MDEL group relative to MDS with 17 unique genes significantly under-expressed including various collagen genes (COL1A1, COL1A2, COL3A1, COL5A1, COL18A1), proteoglycans (CSPG4), blood vessel survival factors (ANGPTL4), growth factors (FGF9) and early response genes downstream of growth factors such as ZFP36L1. The gene discussed is COL3A1; the disease is myelodysplastic syndrome.