AR and Familial prostate cancer: Advanced prostate cancer has been shown to depend on multiple aberrant pathways.4 Therefore, CYP17 inhibition prior to docetaxel therapy could potentially prove to have enhanced antitumor effect.44 However, other studies have shown that taxane-mediated anticancer effects might be related in part to their ability to inhibit nuclear transport of AR.66 To this end, it is now appreciated that the AR protein associates with microtubules and translocates to the nucleus via the motor protein dynein.